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Nolvadex (tamoxifen) blocks the actions of estrogen, a female hormone. Certain types of breast cancer require estrogen to grow. Tamoxifen is used to treat and prevent some types of breast cancer.

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Uses

Tamoxifen is used for the treatment of invasive breast cancer, the most common type of breast cancer, following surgery and/or radiation and for preventing invasive breast cancer in women at high risk for developing it. Tamoxifen also is used for the treatment of women following surgery and radiation for a less common type of breast cancer called ductal carcinoma in situ (DCIS or intraductal carcinoma). Women who have had ductal carcinoma in situ are at high risk for developing invasive breast cancer at a later date, and tamoxifen prevents development of the invasive cancer in almost half of the women during the first five years of treatment. Occasionally, tamoxifen is used to stimulate ovulation.

How to take

Tamoxifen should be taken at doses specifically directed by the physician. Currently, long term dosing is recommended (in excess of 2 years). Tamoxifen can be taken with food.

Side effects

The most common side effects associated with tamoxifen are: hot flashes, weight gain, abnormal menstrual periods, and nausea.

Precaution

Tell your doctor your medical history, especially of: eye problems, blood disorders, cancers, liver disease, allergies (especially drug allergies). Use reliable birth control (e.g., proven barrier methods) during treatment and for at least two months after treatment. Consult your doctor or pharmacist. This drug is not recommended for use during pregnancy. Consult your doctor before using this drug. It is not known if this drug is excreted into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Drug interactions

Tamoxifen can cause abnormalities of liver tests and other blood tests, and patients taking it should keep appointments for blood work to monitor for these side effects. Patients should report any suspected side effects immediately, especially bleeding and yellowing of the skin.

Missed dose

If you miss a dose, take as soon as remembered; do not take if it is almost time for the next dose, instead, skip the missed dose and resume your usual dosing schedule. Do not "double-up" the dose to catch up.

Storage

Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.