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AUGMENTIN (Amoxicillin/clavulanic acid) is a penicillin-type antibiotic used to treat a wide variety of bacterial infections such as lower respiratory, middle ear, sinus, skin, and urinary tract infections that are caused by certain specific bacteria. With the help of AUGMENTIN, you will better again in no time.

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Uses

AUGMENTIN is a penicillin-type antibiotic used to treat a wide variety of bacterial infections.
AUGMENTIN is used in the treatment of lower respiratory, middle ear, sinus, skin, and urinary tract infections that are caused by certain specific bacteria. These bacteria produce a chemical enzyme called beta lactamase that makes some infections particularly difficult to treat.

How to take

AUGMENTIN should be taken every 8 or 12 hours, depending on the dosage strength. It may be taken with or without food, but taking it with meals or snacks will help prevent stomach upset. However, the extended-release form, AUGMENTIN XR, should always be taken with food to improve absorption.

Side effects

Diarrhea, nausea, or vomiting may occur during the first few days as your body adjusts to the medication. Take with food to minimize stomach upset. If any of these effects persist or worsen, contact the doctor or pharmacist promptly. This medicine may cause temporary staining of the teeth. Proper brushing will usually remove this staining and may prevent it from occurring. Tell the doctor immediately if any of these highly unlikely but very serious side effects occur: easy bruising or bleeding, persistent sore throat or fever, dark urine, persistent nausea or vomiting, severe stomach/abdominal pain, yellowing eyes or skin. This medication may rarely cause a severe intestinal condition (pseudomembranous colitis) due to a resistant bacteria. This condition may occur weeks after treatment has stopped. Do not use anti-diarrhea products or narcotic pain medications if you have the following symptoms because these products may make them worse. Tell the doctor immediately if you develop: persistent diarrhea, abdominal or stomach pain/cramping, or blood/mucus in your stool. Use of this medication for prolonged or repeated periods may result in oral thrush or a new vaginal yeast infection (oral or vaginal fungal infection). Contact the doctor if you notice white patches in your mouth, a change in vaginal discharge or other new symptoms. A serious allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of a serious allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact the doctor or pharmacist.

Precaution

While AUGMENTIN possesses the characteristic low toxicity of the penicillin group of antibiotics, periodic assessment of organ system functions, including renal, hepatic, and hematopoietic function, is advisable during prolonged therapy.
A high percentage of patients with mononucleosis who receive ampicillin develop an erythematous skin rash. Thus, ampicillin-class antibiotics should not be administered to patients with mononucleosis.
The possibility of super infections with mycotic or bacterial pathogens should be kept in mind during therapy. If super infections occur (usually involving Pseudomonas or Candida), the drug should be discontinued and/or appropriate therapy instituted.
Prescribing AUGMENTIN in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

Drug interactions

Probenecid decreases the renal tubular secretion of amoxicillin. Concurrent use with AUGMENTIN may result in increased and prolonged blood levels of amoxicillin. Co administration of probenecid cannot be recommended.
The concurrent administration of Allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving ampicillin alone. It is not known whether this potentiating of ampicillin rashes is due to Allopurinol or the hyperuricemia present in these patients. There are no data with AUGMENTIN and Allopurinol administered concurrently.
In common with other broad-spectrum antibiotics, AUGMENTIN may reduce the efficacy of oral contraceptives.

Missed dose

Take it as soon as you remember. If it is almost time for the next dose, and you take 2 doses a day, take the one you missed and the next dose 5 to 6 hours later. If you take 3 doses a day, take the one you missed and the next dose 2 to 4 hours later. Then go back to your regular schedule.

Storage

Store at room temperature between 59 and 86 degrees F (between 15 and 30 degrees C) away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.