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Amaryl (Glimepiride) is used with diet and exercise to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood).

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Uses

Glimepiride (glye-MEP-i-ride) is an anti-diabetic drug (sulfonylurea-type) used along with a proper diet and exercise program to control high blood sugar. Glimepiride stimulates your pancreas to make more insulin and also makes your body more sensitive to insulin. Glimepiride may be used with or without insulin. This medication is sometimes prescribed for other uses; ask your doctor for more information.

How to take

Take Glimepiride tablets by mouth. Swallow the tablets with a drink of water. Take your dose at the same time each day, with breakfast or your first large meal; do not take more often than directed.

Side effects

Diarrhea, headache, heartburn, stomach discomfort, increased sensitivity to the sun, nausea, vomiting, skin rash, redness, swelling, or itching.
These side effects usually do not require medical attention. Report to your prescriber or health care professional if they continue or are bothersome.
Side effects that you should report to your prescriber or health care professional as soon as possible:
Anxiety or nervousness; confusion, difficulty concentrating, blurred vision, breathing difficulties or excessive phlegm; cold sweats, increased sweating, cool, pale skin, coughing up blood, dark yellow or brown urine; dizziness, drowsiness, excessive hunger, fast heartbeat, palpitations, chest pain, fever, chills, sore throat, seizures (convulsions), tremor or shakiness; unusual bleeding or bruising; unusual tiredness or weakness.

Precaution

Check with your prescriber or health care professional if your blood sugar is high; you might need to change the dose of Glimepiride. Do not skip meals. If you are exercising much more than usual, you might need extra snacks to avoid side effects caused by low blood sugar. Alcohol can increase possible side effects of Glimepiride. Ask your prescriber or health care professional if you should avoid alcohol. Glimepiride can increase the sensitivity of your skin to the sun. Keep out of the sun, or wear protective clothing outdoors and use a sunscreen. Do not use sun lamps or sun tanning beds or booths. If you are going to have surgery, tell your prescriber or health care professional that you are taking Glimepiride. Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

Drug interactions

The following drugs may interact with Glimepiride:
Bosentan, medicines for fungal or yeast infections (examples: fluconazole, itraconazole, voriconazole), Rifampin, Warfarin.
Tell your prescriber or health care professional: about all other medicines you are taking including nonprescription medicines; if you are a frequent user of drinks with caffeine or alcohol; if you smoke; or if you use illegal drugs. These can affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

Missed dose

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

Storage

Store at room temperature below 30 degrees C (86 degrees F). Throw away any unused medicine after the expiration date.